Seraphim are angels that fly above God’s throne while Cherubs guard the throne. Uriel and Gabriel may be based on Seraph and Cherub angels."But," He said, "you cannot see my face, for man shall not see me and live.".This is in reference to Exodus 33:20 in the Bible. Uriel and Gabriel, along with the angel statues, have no face.Gabriel is an archangel who typically serves as a messenger sent from God to certain people in Abrahamic religions.The name means "God is my light" - in Hebrew, ori (or uri) means "my light" and el means "god". Uriel (or Auriel/Oriel) is one of the archangels of post-Exilic Rabbinic tradition, and also of certain Christian traditions.As a result, it is possible to miss obtaining Key Piece 1 while getting Key Piece 2.When returning to the Sacrifice Room, the angel will be gone.When spawned inside a Sacrifice Room, the room is not locked, allowing Isaac to simply walk out of the fight.Uriel and Gabriel are immune to the Fear effect.Both angels will drop key pieces if fought at the same time.If each angel is spawned and defeated separately, both will drop Key Pieces. Destroying both at the same time will spawn both Uriel and Gabriel, but only one Key Piece will drop. Sometimes, two angel statues can appear in the same room.Angels will drop items from the Angel Room item pool instead of the Key Pieces if Isaac is holding Filigree Feather.The hitbox for the angel's beams of light are off and causes Isaac to take damage if he is anywhere near them, even if he does not touch the beam.Rerolling the Key Pieces in an Angel Room will yield an item from the Angel Room item pool.Rerolling Key Piece 1 or Key Piece 2 will yield an item from a pool, depending on which room the Key Pieces are in.Additionally, if Isaac has one of the Key Pieces, angels will always drop the other piece, even if he already skipped that piece or that particular angel normally wouldn't drop it (for instance, Uriel will drop Key Piece 2 if Isaac already has Key Piece 1 from fighting him earlier). Angels will drop a Key Piece even if they were defeated before.
This only happens when the angel statue is spawned in a Secret Room in Chapter 1. Likewise, if an angel is killed in Chapter 1, no parts of the key are dropped.However, if this occurs, it counts as a normal room clear, and the player may be rewarded with a pickup or chest. If the player defeats an angel and they already have both Key Pieces, no Key Piece drops.Thus, if Uriel has just been defeated, the next angel spawn is guaranteed to be Gabriel and vice versa. The angels will always alternate in order of appearance.Angelic Prism - Defeat an Angel 10 times.